Inhibition of CXCR1/2 reduces the emperipolesis between neutrophils and megakaryocytes in the Gata1low model of myelofibrosis

The word “emperipolesis” (from the Greek word meaning “inside wandering”) was first used by Humble et al in 1956 to describe the passage of cancer cells inside megakaryocytes (1). Later studies defined emperipolesis as the random passage of one cell through the cytoplasm of another with no pathologic al consequence for either one of them. It was then discovered that emperipolesis is particularly frequent in megakaryocytes since by transmission electron microscopy up to 5% of those present in a normal bone marrow section are engulfed with other cell types, including red blood cells and neutrophil s (2).

Source: Experimental Hematology - February 28, 2023 Category: Hematology Authors: Francesca Arciprete, Paola Verachi, Fabrizio Martelli, Mauro Valeri, Manjola Balliu, Paola Guglielmelli, Alessandro Maria Vannucchi, Anna Rita Migliaccio, Maria Zingariello Tags: Article Source Type: research