Amyloid-like IgM Deposition Neuropathy with Multiple Mononeuropathies and Generalized Neuropathy

Immunoglobulin M (IgM) monoclonal gammopathy is the most common subtype of paraproteinemia to cause neuropathy. The well-known characteristics of many IgM associated neuropathies are distal acquired demyelinating symmetric neuropathy (DADS) presenting as painless sensory ataxia and to a lesser degree, chronic inflammatory demyelinating polyneuropathy (CIDP) phenotype. Other possible manifestations are multiple mononeuropathy due to IgM related microvasculitis with mixed cryoglobulinemia, light chain amyloidosis, neurolymphomatosis from an underlying hematologic malignancy and rarely, IgM deposition neuropathy [1 –3].

Source: Neuromuscular Disorders - February 23, 2023 Category: Neurology Authors: Pannathat Soontrapa, Christopher J. Klein, P. James B. Dyck, Sarah E. Berini, Ellen D. McPhail, Moritz Binder, Pitcha Chompoopong, JaNean Engelstad, Kamal Shouman Tags: Case report Source Type: research