Effects of topiramate therapy on serum bicarbonate concentration in a sample of 10,279 veterans

CONCLUSIONS: The excess prevalence of metabolic acidosis associated with topiramate treatment does not differ with dosage, alcohol consumption, or the presence of an AUD. Baseline and periodic serum bicarbonate concentration measurements are recommended during topiramate therapy. Patients prescribed topiramate should be educated about the symptoms of metabolic acidosis and urged to report their occurrence promptly to a healthcare provider.PMID:36810985 | DOI:10.1111/acer.15011
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research