Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation

Discussion
GAD65-specific B cells are present in the CNS and represent a sizable fraction of CSF B cells early in the disease course. The anti-GAD65 response in the CSF is polyclonal and shows evidence of antigen-driven affinity maturation required for GAD65 recognition. Our data support the hypothesis that the accumulation of GAD65-specific B cells and plasma cells in the CSF is an important feature of early disease stages.

Source: Neurology Neuroimmunology and Neuroinflammation - February 23, 2023 Category: Neurology Authors: Biljecki, M., Eisenhut, K., Beltran, E., Winklmeier, S., Mader, S., Thaller, A., Eichhorn, P., Steininger, P., Flierl-Hecht, A., Lewerenz, J., Kümpfel, T., Kerschensteiner, M., Meinl, E., Thaler, F. S. Tags: All Immunology Research Article Source Type: research