Friedel – Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs)

Abstract
An iron(III) chloride hexahydrate-catalyzed Friedel–Crafts acylation of benzene derivatives in tunable aryl alkyl ionic liquids (TAAILs) has been developed. Through optimization of the metal salt, reaction conditions and ionic liquids, we were able to design a robust catalyst system that tolerates different electron-rich substrates under ambient atmosphere and allows for a multigram scale.

Beilstein J. Org. Chem. 2023, 19, 212–216. doi:10.3762/bjoc.19.20

Source: Beilstein Journal of Organic Chemistry - February 23, 2023 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: Friedel – Crafts acylation homogeneous catalysis ionic liquids iron catalysis TAAILs Full Research Paper Source Type: research