The Alzheimer ’s disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130

The protease BACE1 is a major drug target for Alzheimer ’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological ...

Source: Molecular Neurodegeneration - February 21, 2023 Category: Neurology Authors: Stephan A. M üller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy and Stefan F. Lichtenthaler Tags: Research article Source Type: research