Evolution in the Pathologic Classification of Renal Neoplasia

The pathologic classification of renal tumors is a dynamic and complex process, which has evolved to a “histomolecular” driven system. Despite advances in molecular characterization, most renal tumors can be diagnosed by morphology with or without using a limited set of immunohistochemical stains. If access to molecular resources and specific immunohistochemical markers is limited, pathologists m ay face difficulties in following an optimal algorithm to classify renal tumors. In this article, we detail the historical evolution of renal tumor classification, including a synopsis of major changes introduced by the current fifth edition World Health Organization 2022 classification of renal epi thelial tumors.
Source: Urologic Clinics of North America - Category: Urology & Nephrology Authors: Source Type: research