Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury

Angiogenesis helps to improve neurological recovery by repairing damaged brain tissue and restoring cerebral blood flow (CBF). The role of the Elabela (ELA)-Apelin receptor (APJ) system in angiogenesis has gained much attention. We aimed to investigate the function of endothelial ELA on post-ischemic cerebral angiogenesis. Here, we demonstrated that the endothelial ELA expression was upregulated in the ischemic brain and treatment with ELA-32 mitigated brain injury and enhanced the restoration of CBF and newly formed functional vessels following cerebral ischemia/reperfusion (I/R) injury.

Source: Translational Research - February 20, 2023 Category: Research Authors: Wenyu Li, Pengfei Xu, Lingqi Kong, Shuo Feng, Nan Shen, Hongmei Huang, Wuxuan Wang, Xiang Xu, Xinyue Wang, Guoping Wang, Yan Zhang, Wen Sun, Wei Hu, Xinfeng Liu Source Type: research