Performance of QuantiFERON-TB Gold Plus assays in paediatric tuberculosis: a multicentre PTBNET study

Conclusions The results indicate that the latest generation IGRA assay, QFT-Plus, does not perform better than previous generation IGRAs or the TST in children with TB disease. Overall, tests performed worse in CNS and miliary TB, and in immunocompromised children. None of the tests evaluated had sufficiently high sensitivity to be used as a rule-out test in children with suspected TB.

http://thorax.bmj.com/cgi/content/short/78/3/288?rss=1

Source: Thorax - February 16, 2023 Category: Respiratory Medicine Authors: Buonsenso, D., Noguera-Julian, A., Moroni, R., Hernandez-Bartolome, A., Fritschi, N., Lancella, L., Cursi, L., Soler-Garcia, A., Krüger, R., Feiterna-Sperling, C., Sali, M., Lo Vecchio, A., Scarano, S., Hernanz Lobo, A., Espiau, M., Soriano-Arande Tags: Editor's choice, Thorax Tuberculosis Source Type: research