Sex-Specific Association of SELL Gene Polymorphisms with Pattern Hair Loss in the Thai Population: A Candidate Gene Association Study and In Silico Functional Characterization

Pattern hair loss (PHL) is a common heritable trait affecting both males and females (MPHL and FPHL, respectively). Although follicular miniaturization is the hallmark of PHL, assumptions implicating inflammatory infiltration around perifollicular areas have received attention. Leukocyte migration requires L-selectin, which is encoded by SELL. Several genes, including AR and SRD5A2, were associated with PHL under a non-Asian genetic architecture in a previous genome-wide association study [1]. However, no study has yet evaluated the possible genetic effects of SELL polymorphisms in PHL.

Source: Journal of Dermatological Science - February 14, 2023 Category: Dermatology Authors: Chiranan Khantham, Warintorn Ruksiriwanich, Tanakarn Chaitep, Pichchapa Linsaenkart, Anurak Muangsanguan, Andrea Guzm án-Jiménez, Miriam Cerván-Martín, Lara Bossini-Castillo, Sara Gonzalez-Muñoz, Rogelio J. Palomino-Morales, Nipapan Leetrakool, Banph Tags: Letter to the Editor Source Type: research