Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology

The rare p.H157Y variant of TREM2 (Triggering Receptor Expressed on Myeloid Cells 2) was found to increase Alzheimer ’s disease (AD) risk. This mutation is located at the cleavage site of TREM2 extracellular domai...

Source: Molecular Neurodegeneration - January 31, 2023 Category: Neurology Authors: Wenhui Qiao, Yixing Chen, Jun Zhong, Benjamin J. Madden, Cristine M. Charlesworth, Yuka A. Martens, Chia-Chen Liu, Joshua Knight, Tadafumi C. Ikezu, Kurti Aishe, Yiyang Zhu, Axel Meneses, Cassandra L. Rosenberg, Lindsey A. Kuchenbecker, Lucy K. Vanmaele, Tags: Research article Source Type: research