Evaluation of Single Nucleotide Variants in Intron 1 of the ABO Gene as Diagnostic Markers for the A < sub > 1 < /sub > Blood Group

Conclusion: TheABO intron 1 variants revealed significant association with theABO*A1 allele and the A phenotype. However, the intron 1 genotype does not exclude variant alleles causing weak A phenotypes. With the introduction of reliable tag, single nucleotide variants for the A1, A2, B, and O blood groups and the genotyping instead of phenotyping of the ABO blood group are getting more feasible on a routine basis.Transfus Med Hemother

Source: Transfusion Medicine and Hemotherapy - January 18, 2023 Category: Hematology Source Type: research