Comparison of Chorioretinal Parameters in Diabetic Retinopathy with or without Pan-retinal Photocoagulation Using Ultrawide-field Swept Source Optical Coherence Tomography Angiography

Purpose To compare structural and vascular parameters in the central and peripheral retina and choroid of eyes diagnosed with severe non-proliferative diabetic retinopathy (NPDR) or proliferative diabetic retinopathy (PDR) with or without pan-retinal photocoagulation (PRP) using ultrawide-field wept-source optical coherence tomography angiography (SS-OCTA). Methods All participants underwent SS-OCTA imaging centered on the fovea. Retinal and choroidal thickness, vessel density of the superficial capillary plexus (SCP), deep capillary plexus (DCP), choroidal capillary plexus (CCP), and choroidal Sattler ’s and Haller’s layer (CSHL) were analyzed in nine grids using built-in angiography analysis software. Results A total of 82 eyes from 82 participants were enrolled in this study, including 40 eyes diagnosed with severe NPDR or PDR without PRP and 42 eyes with PRP. Retinal thickness in part grid s was higher in eyes with PRP than in eyes without PRP. Vessel density of the SCP in nasal-superior (P = 0.003) grid was lower in eyes with PRP than in eyes without PRP. No significant difference was found in the vessel density of the DCP between the two groups (all P> 0.05). The choroidal thickness and vessel density of the CSHL of all grids significantly lower in eyes with PRP than in eyes without PRP (all P
Source: Ophthalmic Research - Category: Opthalmology Source Type: research