Metabolic switch in cancer – Survival of the fittest
Cell metabolism is characterised by the highly coordinated conversion of nutrients into energy and biomass. In solid cancers, hypoxia, nutrient deficiencies, and tumour vasculature are incompatible with accelerated anabolic growth and require a rewiring of cancer cell metabolism. Driver gene mutations direct malignant cells away from oxidation to maximise energy production and biosynthesis while tumour-secreted factors degrade peripheral tissues to fuel disease progression and initiate metastasis.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Hans Raskov, Shruti Gaggar, Asma Tajik, Adile Orhan, Ismail G ögenur Tags: Review Source Type: research