Echinocandin exposures in obese patients: A scoping review and clinical perspectives

CONCLUSION: This scoping review shed light on a growing body of evidence indicating that obese patients have lower echinocandin exposures relative to targeted PK indices, which may lead to negative therapeutic implications. Currently, a lack of high-quality evidence impedes reaching consensus on recommendations for echinocandin dosing adjustment in obese patients. Future research evaluating the optimal echinocandin dosing strategy for obese patients is needed.PMID:36680786 | DOI:10.1093/ajhp/zxad021

Source: American Journal of Health-System Pharmacy : AJHP - January 21, 2023 Category: Drugs & Pharmacology Authors: Yazed S Alsowaida Ahmed Alamer Abrar K Thabit Abdulaziz S Almulhim Muneerah M Aleissa Alireza Kalbasi Khaled Eljaaly Thamer A Almangour Brian L Erstad Source Type: research