Journal club

Catheter-directed thrombolysis for submassive pulmonary embolism: meta-analysis supports improved outcomes compared with anticoagulation alone The literature shows conflicting results on the use of catheter-directed thrombolysis (CDT) and systemic anticoagulation (SA) alone in patients suffering submassive pulmonary emboli (sPE). Ismayl et al (Am J Cardiol 2022;178:154) conducted a meta-analysis, which included the results from 11 observational and 1 randomised clinical trials. The analysis compared the outcomes of 1871 patients who received both CDT and SA, to the outcomes of a second group composed of 7918 patients, who received (SA) alone. The use of CDT was associated with significantly lower in-hospital mortality (relative risk (RR) 0.41, 95% CI 0.30 to 0.56, p<0.001, I2=0%), 30-day mortality (RR 0.37, 95% CI 0.18 to 0.73, p=0.004, I2=0%), 90-day mortality (RR 0.36, 95% CI 0.17 to 0.72, p=0.004, I2=0%) and a tendency toward lower 1-year mortality (RR 0.56, 95% CI 0.29 to 1.05, p=0.07, I2=36%) compared with SA....
Source: Thorax - Category: Respiratory Medicine Authors: Tags: Thorax Journal club Source Type: research