Molecules, Vol. 28, Pages 755: In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents

Molecules, Vol. 28, Pages 755: In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents Molecules doi: 10.3390/molecules28020755 Authors: Goutam Mondal Olivia R. Dale Yan-Hong Wang Shabana I. Khan Ikhlas A. Khan Charles R. Yates The application of essential oils has historically been limited to topical (massage therapy) and inhalational (aromatherapy) routes of administration. More recently, however, evaluation of the therapeutic effects of essential oils has expanded to include the oral route of administration, which increases the herb–drug interaction potential. The purpose of this study was to evaluate the herb–drug interaction potential of lavender essential oil and two of its primary phytoactive constituents, namely linalool and linalyl acetate. The metabolic stability of linalool and linalyl acetate was determined in human liver microsomes (HLM) and S9 fractions by quantitative analysis using UPLC-MS/MS system. Linalool was metabolically unstable in HLM and S9 fractions with an intrinsic clearance of 31.28 mL·min−1·kg−1, and 7.64 mL·min−1·kg−1, respectively. Interestingly, it was observed that linalyl acetate converted to linalool both in HLM and S9 fractions. Lavender oil showed weak inhibitory effect on the catalytic activity of CYP3A4 and CYP1A2 enzymes (IC50 12.0 and 21.5 &...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research