A t(4;13)(q21;q14) translocation in B-cell chronic lymphocytic leukemia causing concomitant homozygous DLEU2/miR15a/miR16-1 and heterozygous ARHGAP24 deletions

13q14 deletion is the most recurrent chromosomal aberration in B-cell Chronic Lymphocytic Leukemia (B-CLL) (50% of the patients) [1], considered a good prognostic factor as a sole cytogenetic aberration [2], even though the clinical course of such patients depends on the deletion size and the number of cells with the del(13)(q14) deletion [3 –6]. Two deletions (Type 1 and 2) are described according to their size, both encompassing the DLEU2/miR15a/miR16-1 genes, with the Type 2 deletions including the RB1 gene [7].

Source: Cancer Genetics and Cytogenetics - January 6, 2023 Category: Genetics & Stem Cells Authors: Doron Tolomeo, Antonio Agostini, Antonio Giovanni Solimando, Crocifissa Lo Cunsolo, Lorella Cimarosto, Orazio Palumbo, Pietro Palumbo, Massimo Carella, Maria Hern ández-Sánchez, Jesús María Hernández-Rivas, Clelia Tiziana Storlazzi Source Type: research