Impact of solute carrier transporter gene polymorphisms on serum creatinine concentrations in healthy volunteers

In this study, muscle mass, serum cystatin C concentration, body fat percentage, serum albumin concentration, and MATE2-K gene polymorphism were independent factors affecting serum creatinine concentration. TheSLC47A2 c.-130G  >  A polymorphism may affect creatinine dynamics in the proximal tubules. AbstractIn this study, we investigated the impact of single nucleotide polymorphisms in solute carrier (SLC) transporters, that is,SLC22A7 c.1586  + 206A >  G,SLC22A2 c.808G  >  T,SLC22A3 c.1233G  >  A,SLC47A1 c.922-158G  >  A, andSLC47A2 c.-130G  >  A, on serum creatinine (SCr) concentrations. This cross-sectional study included residents who participated as volunteers in a health promotion study. Lifestyle data, blood chemical analysis data, and SLC gene polymorphism information were collected from each participant. Univariate analyses were carried out to determine differences between groups and correlations in SCr. Stepwise multiple regression analysis was performed to confirm the independence of factors that were significantly different in the univariate analyses. In multiple regression analyses, muscle mass, serum cystatin C concen trations, body fat percentage, serum albumin concentrations, andSLC47A2 c.-130G/G had the highest contribution to SCr concentrations, in that order (standardized regression coefficients  = .505, .332, −.234, .123, and .084, respectively). The final model explained 72.2% of the variability in SCr con...
Source: Pharmacology Research and Perspectives - Category: Drugs & Pharmacology Authors: Tags: INVITED REVIEW Source Type: research