Dengue virus induced autophagy is mediated by HMGB1 and promotes viral propagation

This study shows that the modulation of autophagy by DENV-2 is HMGB1/BECN1 dependent. In addition, glycyrrhizic acid (GA), a potent HMGB1 inhibitor suppressed autophagy as well as DENV-2 replication. Altogether, our data suggests that HMGB1 induces BECN1 dependent autophagy to promote DENV-2 replication.PMID:36587643 | DOI:10.1016/j.ijbiomac.2022.12.299
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research