Transcriptional expression and prognostic roles of MCM7 in human bladder, breast, and lung cancers: a multi-omics analysis

AbstractMinichromosome Maintenance Complex Component 7 (MCM7) protein is associated with cell proliferation in cancer and that might play an important role in human cancer. Here, we examined a systematic analysis to identify the expression and prognosis pattern of MCM7 gene in different cancer. Initially, we examined publicly available online platforms such as Oncomine, TIMER, cBioportal, PrognoScan, and  NetworkAnalyst to identify the expression pattern of MCM7 in human cancers. Our analysis revealed the higher transcriptional expression of MCM7 gene in different cancers, but overall expression analysis showed that bladder, breast, and lung cancers are most significant and these cancers show posit ive correlation with immune infiltration. We also identified a group of notable protein interactions with MCM7 by PPI (protein–protein interaction) analysis. We observed that MCM7 showing the high mRNA expression is positively correlated with the low survival rate in human bladder, breast, and lun g cancers. In addition, we analyzed mutations and copy number alterations in MCM7 genes in various types of cancers using cBioPortal. Most of the functional enrichment found in this study were related to cell division or cell cycle regulation. Subsequently, our results suggest MCM7 is highly expres sed during the cancer development process and prospective therapeutic target for human bladder, breast, and lung cancers. Therefore, targeting the protein can be used as early diagnosis opt...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - Category: Bioinformatics Source Type: research