Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt –GSK–3β–Nrf2 pathway

ConclusionsThe loss of PHLPP2 was beneficial for HG-injured RGCs through the effect on the Akt –GSK–3β–Nrf2 pathway. This work suggests a possible role of PHLPP2 in diabetic retinopathy.
Source: Inflammation Research - Category: Research Source Type: research