Evaluation of renal glucose uptake with [18F]FDG-PET: Methodological advancements and metabolic outcomes

Studying renal glucose metabolism non-invasively in humans is an unmet need. Positron emission tomography (PET) is the current gold standard for measuring regional tissue glucose uptake rates, but the most widely used glucose analog ([18F]FDG) is not a good substrate for sodium-glucose cotransporters (SGLTs). As a consequence, [18F]FDG spills over into the urine and [18F]FDG-PET considerably underestimates published rates of whole renal glucose uptake obtained using the arterial-venous difference technique.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research