Hepatocyte Ninjurin2 promotes hepatic stellate cell activation and liver fibrosis through the IGF1R/EGR1/PDGF-BB signaling pathway

Liver fibrogenesis is orchestrated by the paracrine signaling interaction between several resident cell types regulating the activation of hepatic stellate cells (HSCs). However, the molecular mechanisms underlying paracrine regulation are largely unknown. The aim of this study is to elucidate the role of Ninjurin2 in the crosstalk between hepatocytes and HSCs and better understand the implications of Ninjurin2 in liver fibrosis.

Source: Metabolism - Clinical and Experimental - December 19, 2022 Category: Biomedical Science Authors: Yifan Wang, Pengyun Wang, Yubing Yu, Erwen Huang, Yufeng Yao, Di Guo, Huixin Peng, Beijia Tian, Qian Zheng, Mengru Jia, Jing Wang, Xinna Wu, Jianding Cheng, Huiying Liu, Qing K. Wang, Chengqi Xu Source Type: research