Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis

Oxidative stress (OS) is the main cause leading to diabetic renal fibrosis. Recently, Fyn was paid much attention on OS and emerged as a pivotal player in acute kidney injury, while whether Fyn regulates oxidative stress in chronic diabetes nephropathy (DN) has not been clarified yet. The purpose of this study was to identify the role of Fyn in DN and elucidated its regulatory mechanism.

Source: Metabolism - Clinical and Experimental - December 17, 2022 Category: Biomedical Science Authors: Shanshan Li, Zhanchi Xu, Zeyuan Lin, Haiming Xiao, Chuting Li, Jingran Zeng, Xi Xie, Li Deng, Heqing Huang Source Type: research