Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

ConclusionsWe present a link between LOY and an acute, life-threatening infectious disease. Furthermore, this study highlights LOY as the most prominent clonal mutation affecting the myeloid cell lineage during emergency myelopoiesis. The correlation between LOY level and COVID-19 severity might suggest that this mutation affects the functions of monocytes and neutrophils, which could have consequences for male innate immunity.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research