CaMKII and reactive oxygen species contribute to early reperfusion arrhythmias, but oxidation of CaMKII δ at methionines 281/282 is not a determining factor

Available evidence suggest that Ca2+/calmodulin-dependent protein kinase type II δ (CaMKIIδ) and reactive oxygen species (ROS) are important in early ischemia-reperfusion arrhythmias (IRA). Since ROS can activate CaMKIIδ by oxidation of two methionines at positions 281/282, oxidized-CaMKIIδ (Ox-CaMKIIδ) has been proposed to be important for IRA. However, direct evidence for this is missing.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research