Higher prepubertal IGF-1 concentrations associate to earlier pubertal tempo in both sexes

Introduction: Pubertal onset is triggered by multiple neuroendocrine interactions. The role of prepubertal IGF-1 in this process has not been explored in both sexes. Our objective is to analyze the association of prepubertal IGF-1 concentration with age at thelarche (B2) and menarche (M) in girls and age at gonadarche (G2) in boys. Methods: Longitudinal study (n=1196 boys and girls) within the Growth and Obesity Chilean cohort Study (GOCS). At ages ≈ 6.7 years blood sample for IGF-1. Subjects analyzed into 4 groups according to the onset age of the pubertal event. Results: Higher prepubertal IGF-1 levels were observed at earlier ages of thelarche (p=0.003) and menarche onset (p=0.041). A taller prepubertal height was observed at younger age s of thelarche and menarche (p=
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research