Ischaemic stroke as the first presentation of antineutrophilic cytoplasmic autoantibody ‐associated vasculitis

We present the case of a 71-year-old woman with positive myeloperoxidase antineutrophil cytoplasmic antibodies and negative proteinase 3 autoantibodies. The patient presented with 1  week history of pyramidal weakness in both upper and lower limbs, hyperreflexia, and clonus. Magnetic resonance imaging of the brain demonstrated widespread bihemispheric cortical and deep white matter acute infarcts, which are consistent with features of stroke secondary to vasculitis. Myelopero xidase antineutrophilic cytoplasmic autoantibody-positive vasculitis diseases are more commonly associated with renal, pulmonary, and cutaneous manifestations; however, in our patient, the central nervous system features predominated. This case highlights the challenges of diagnosing primary central nervous system vasculitis, in this case, an atypical myeloperoxidase antineutrophilic cytoplasmic autoantibody-positive disease without the classical disease course and clinical signs.

Source: Clinical Case Reports - December 10, 2022 Category: General Medicine Authors: John Chuan Nguyen Tran, Joshua Haron Abasszade, Yew Li Dang, Douglas Ewan Crompton Tags: CASE REPORT Source Type: research