Gold –oxoborate nanocomposite‐coated orthodontic brackets gain antibacterial properties while remaining safe for eukaryotic cells

BOA (B —boron, O—oxygen, A—gold, Latinaurum) nanocomposite reduces the adhesion ofStreptococcus mutans to fixed orthodontic brackets by around 78% compared to noncoated appliances. Modified brackets remained safe for eukaryotic cells and meet ISO 10993-5:2009 requirements for medical devices. BOA coating is mechanically stable against brushing with a toothbrush, and its application is straightforward, effective, and ecologically friendly. AbstractThe study's main objective is to limit bacterial biofilm formation on fixed orthodontic appliances. Bacterial biofilm formation on such devices (e.g., brackets) causes enamel demineralization, referred to as white spot lesions (WSL). WSL is significant health, social and economic problem. We provide a nanotechnology-based solution utilizing a nanocomposite of gold nanoparticles embedded in a polyoxoborate matrix (BOA: B —boron, O—oxygen, A—gold, Latinaurum). The nanocomposite is fully inorganic, and the coating protocol is straightforward, effective, and ecologically friendly (low waste and water-based). Prepared coatings are mechanically stable against brushing with a toothbrush (up to 100  min of brushing). Bacteria adhesion and antibacterial properties are tested againstStreptococcus mutans—common bacteria in the oral cavity. BOA reduces the adhesion of bacteria by around 78%, that is, from around 7.99 × 105 ± 1.33 × 105 CFU per bracket to 1.69 × 105 ± 3.07 × 104 CFU per bracket ofS.mu...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - Category: Materials Science Authors: Tags: RESEARCH ARTICLE Source Type: research