Seven Years of SNPs: An Assessment of Methods Utilized for Generating Profiles for Forensic Genetic Genealogy

Over the past seven years, hundreds of cases have been processed with the goal of phenotyping, biogeographical ancestry, and/or forensic genetic genealogy (FGG) research. However, not all profiles developed were suitable for upload to public databases or for phenotype and ancestry estimations, while some poor-quality samples surprisingly were. The capabilities for FGG testing have grown in the past year and are still improving. This summary will serve to compare the results that can be expected from three very different DNA profiling systems; single nucleotide polymorphism (SNP) array, whole genome sequencing (WGS), and targeted SNP testing via next generation sequencing (NGS).
Source: Forensic Science International: Genetics Supplement Series - Category: Forensic Medicine Authors: Source Type: research