Molecules, Vol. 27, Pages 8411: Design of Conjugates Based on Sesquiterpene Lactones with Polyalkoxybenzenes by & ldquo;Click & rdquo; Chemistry to Create Potential Anticancer Agents

Molecules, Vol. 27, Pages 8411: Design of Conjugates Based on Sesquiterpene Lactones with Polyalkoxybenzenes by “Click” Chemistry to Create Potential Anticancer Agents Molecules doi: 10.3390/molecules27238411 Authors: Margarita E. Neganova Ekaterina V. Smirnova Elena V. Sharova Oleg I. Artyushin Yulia R. Aleksandrova Ekaterina Yu. Yandulova Natalia S. Nikolaeva Valery K. Brel Using the methodology of “click” chemistry, a singular method has been developed for the synthesis of unique conjugates based on sesquiterpene lactones: dehydrocostuslactone and alantolactone with polyalkoxybenzenes. To expand the structural range of the resulting conjugates, the length of the 1,2,3-triazole spacer was varied. For all synthesized compounds, the cytotoxic profile was determined on the cell lines of tumor origin (SH-SY5Y, HeLa, Hep-2, A549) and normal Hek 293 cells. It was found that the compounds based on alantolactone 7a–d with a long spacer and substances containing dehydrocostuslactone 10a–d with a short spacer have the greatest toxic effect. The decrease in cell survival under the action of these conjugates may be due to their ability to cause dissipation of the transmembrane potential of mitochondria and inhibit the process of glycolysis, leading to cell death. The obtained results confirm the assumption that the development of conjugates based on sesquiterpene lactones and polyalkoxyben...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research