Predictive Value of Inflammatory Cytokines in Early Pregnancy for Liver Dysfunction in Pregnant Women with Hepatitis B
Horm Metab Res DOI: 10.1055/a-1973-7255The purpose of this study is to explore the predictive value of cytokine levels
in the first trimester of pregnancy on abnormal liver function of pregnant women
with hepatitis B in the third trimester of pregnancy. A total of 111 pregnant
women with HBV infection at 12 weeks gestation participated in the study. The
levels of IL-6, IL-8, TNF-α in peripheral blood of the patients and
liver function indexes were detected. Subsequently, the pregnant women were
followed up, and the liver function was detected at 36 weeks of gestation.
According to liver function indexes, patients were divided into normal liver
function group and abnormal liver function group to determine the correlation
between cytokines in early pregnancy and abnormal liver function in late
pregnancy. Kaplan–Meier survival curve and multivariate Cox analysis
were used to evaluate the predictive value of cytokines for liver dysfunction.
At 12 weeks of gestation, cytokine levels in the normal liver function group
were significantly lower than that in the abnormal liver function group.
Kaplan–Meier survival analysis showed that the increased IL-6 level was
associated with abnormal liver function in late pregnancy. Multivariate Cox
regression analysis revealed that IL-6 level was an independent predictor of
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Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Wang, Wei Jia, Hongyan Wang, Yue Sun, Weize Yang, Can Tags: Original Article: Endocrine Care Source Type: research
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