7. Overview of recurrent and novel gene fusions detected in a clinical diagnostic laboratory

Gene fusions are important mechanism of tumorigenesis, present in a wide range of neoplastic disorders and frequently impacting diagnosis, prognosis and therapy.The clinical use of Next Generation Sequencing technologies has enabled the identification of known and novel gene fusions with variable impact in patient care.The aim of this study is to present an overview of the gene fusions detected in a cohort of patients with solid tumors sequenced in a clinical diagnostic laboratory and to discuss the process of fusion curation for clinical purposes.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research