39. Associations between somatically altered genes and recurrence outcomes in estrogen receptor positive breast cancer
The relationships between somatic mutations, copy number alterations (CNA) and outcomes in estrogen receptor positive (ER+) breast cancer is understudied. We have earlier published associations between rare and low frequency mutations and clinical outcomes in ER+ disease (PMID:30181556).As an extension of the study, FFPE blocks were obtained from 889 additional patients from the TransATAC study, an Anastrozole (A) or Tamoxifen (T) alone or combined randomized trial with 10-year follow-up. Tumor samples were reviewed, DNA isolated, and targeted sequencing performed for 83 genes.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Meenakshi Anurag, Kim Chu, Brian Li, Ivana Sestak, Eugene Schuster, Zachary Skidmore, Nicholas Spies, Jason Kunisaki, Catrina Fronick, Robert Fulton, Malachi Griffith, Richard Buss, Jack Cuzick, Obi L. Griffith, Mitchell Dowsett, Matthew Ellis Source Type: research