72. Variant curation of BCR::ABL1-like B-lymphoblastic leukemia/lymphoma through expert panel consensus

BCR::ABL1-like B-lymphoblastic leukemia/lymphoma (B-ALL) is a neoplasm of precursor B cells and a subtype of high-risk B-ALL that exhibits a gene expression profile similar to that of BCR::ABL1-positive B-ALL while lacking the BCR::ABL1 fusion protein. Instead, it is characterized by somatic variants in a variety of cytokine receptor and kinase encoding genes. This genetic heterogeneity poses challenges for accurate and comprehensive laboratory diagnosis and clinical decision making including prognostication and therapeutic interventions.

Source: Cancer Genetics and Cytogenetics - November 1, 2022 Category: Genetics & Stem Cells Authors: Mark G. Evans, Jason Saliba, Yassmine Akkari, Deepa Bhojwani, Piers Blombury, Arpad Danos, Paul G. Eckert, Mark D. Ewalt, Sandeep Gurbuxani, Christine J. Harrison, Ilaria Iacobucci, Shai Izraeli, Nitin Jain, Rashmi Kanagal-Shamanna, Chim ène Kesserwan, A Source Type: research