Nuclear Factor- κB Clinical Significance in Breast Cancer: An Immunohistochemical Study

Objectives: Nuclear factor κB (NF-κB) is a superfamily of transcription factors that plays a key role in cancer genesis and progression. The present study aimed to explore the exact role of NF-κB/p65 as a marker in breast cancer and its relationship with other prognostic markers, such as tumour grade, tumour size, hormone receptors, and HER-2 expression. Methods: Ninety-nine unselected formalin-fixed paraffin-embedded invasive ductal and lobular tissue sections were evaluated by immunohistochemistry methods to measure NF-κB/p65 expression, ER, PR, HER-2 and Ki-67. The correlation between NF-κB/p65 and clinicopathol ogical parameters was assessed. Results: NF-κB/p65 was only found in the cytoplasm and positively correlated with large tumours (≥2 cm) and high-grade tumours (P
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research