Quantitative Assessment of Bone Marrow Activity Using 18F-FLT PET in Aplastic Anemia and Myelodysplastic Syndromes

Purpose Peripheral cytopenias are typical of blood test abnormalities associated with a variety of conditions, including aplastic anemia (AA) and myelodysplastic syndromes (MDSs). We prospectively investigated the feasibility of quantitative analysis of whole-body bone marrow activity using PET with 3′-deoxy-3′-18F-fluorothymidine (18F-FLT) in AA and MDS. Patients and Methods Sixty-eight patients with cytopenia underwent 18F-FLT PET/MRI scan, with simultaneous bone marrow aspiration and biopsy for hematopoiesis evaluation. SUVs were measured in the vertebrae (Th3, 6, and 9 and L3), bilateral iliac crests, and extremities. SUV and bone marrow pathology were compared between AA and MDS and analyzed in relation to severity of AA and prognosis of MDS. Results Of the 68 patients with cytopenia, 12 were diagnosed with AA, 27 with MDS, 12 with bone marrow neoplasia, 2 with myelofibrosis, and 15 with other conditions. Iliac 18F-FLT SUVs were significantly correlated with bone marrow cell numbers and cell density (r = 0.47, P
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Original Articles Source Type: research