Diagnostic Reliability of CRTC1/3::MAML2 Gene Fusion Transcripts in Discriminating Histologically Similar Intraosseous Mucoepidermoid Carcinoma from Glandular Odontogenic Cyst: A Systematic Review and Meta-analysis

ConclusionsThe current evidence supports that in all cases with positive gene fusion transcript of theCRTC1/3::MAML2 was specific for IMEC and was significantly differentiating it from GOC. Whereas cases of IMEC with negative gene fusion transcript pose diagnostic difficulty in differentiating from a GOC which is negative forCRTC1/3::MAML2 expression.
Source: Head and Neck Pathology - Category: Pathology Source Type: research