Asthma and Anaphylaxis —interconnected entities

AbstractPurpose of reviewThe relationship between asthma and anaphylaxis is not completely defined, and it is necessary to establish their association and find out the influence of factors contributing to their development. Our aim is to review the most recent literature to optimize the diagnostic and therapeutic approach to both entities.Recent findingsIn severe asthma and anaphylaxis, we found a potentially fatal risk. Both diseases can coexist and, although their association is not entirely clear, poor asthma control seems to worsen the prognosis of anaphylaxis.SummaryKnowing the risk factors for the severity of an asthmatic exacerbation could help prevent the occurrence of severe anaphylaxis. What seems clear is that the diagnosis of asthmatic crisis is often superimposed on that of anaphylaxis, and only the associated extra-respiratory symptoms can orient us towards anaphylaxis. Asthmatic crisis and anaphylaxis require a rapid and early approach, with beta2-agonists and adrenaline being the initial treatments of choice. We must consider their pathophysiological mechanism and phenotyping for the choice of specific treatments such as omalizumab, dupilumab, tezepelumab, and ligelizumab, which offer new perspectives in the control and prevention of both asthmatic patients and recurrent anaphylaxis.
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research