Brachytherapy improves survival for inoperable early stage endometrial cancer
Women who have early stage endometrial cancer and are inoperable tend to live longer if they have been treated with brachytherapy with or without external beam radiation, according to new research.
ConclusionsNeoadjuvant chemoradiotherapy effectively downstages the majority of locally-advanced type II endometrial cancers, thereby increasing the likelihood of achieving complete resection with negative margins.
We report our 10-year experience with management of vaginal recurrence using definitive intent re-irradiation brachytherapy with or without EBRT. METHODS: A retrospective review was performed on 22 patients treated with definitive-intent re-irradiation brachytherapy ± EBRT for vaginal recurrence of endometrial cancer. The cumulative rectosigmoid and bladder D2cc (EQD2) were limited to
CONCLUSIONS: Our results suggest brachytherapy benefits stages I-II serous/clear cell cancers, chemotherapy benefits stage III serous/clear cell cancers, and both chemotherapy and brachytherapy benefit stages I-II serous cancers. PMID: 30551884 [PubMed - as supplied by publisher]
We performed this dosimetric study to compare a nonstandard volumetric modulated arc therapy (VMAT) and helical tomotherapy (HT) techniques with high-dose rate (HDR) brachytherapy (BRT) plan of vaginal vault in patients with postoperative endometrial cancer (EC). Twelve postoperative patients with early stage EC were included in this study. Three plans were performed for each patient; dosimetric and radiobiological comparisons were made using dose-volume histograms and equivalent dose for determining the planning target volume (PTV) coverages in brachytherapy and external beam radiotherapy, and organs-at-risk (OARs) doses ...
Conclusions: In our analysis, there were no differences in terms of OS and late toxicity outcomes for patients receiving LDR or HDR VBT. HDR VBT is a safe technique in comparison to LDR VBT. PMID: 30237815 [PubMed]
Endometrial cancer is the most common gynecological cancer in developed countries. Postoperative irradiation has been shown to lower locoregional relapses among high-intermediate risk endometrial cancer patients. In addition, vaginal cuff brachytherapy has demonstrated similar control to external beam radiotherapy but with lower toxicity. Although randomized trials have failed to translate that into better overall survival, reports from large databases, such as the National Cancer Database and the Surveillance, Epidemiology, and End Results database, have shown evidence of a statistical relationship between postoperative i...
Conclusions Our data are consistent with prior studies demonstrating that UEC represents a rare clinical entity characterized by high rates of locally advanced disease at presentation. However, survival outcomes appear to be comparable to other high-grade endometrial cancers. Further studies investigating optimal adjuvant therapy in these patients are warranted.
Publication date: August 2018Source: Journal of the Chinese Medical Association, Volume 81, Issue 8Author(s): Taner Turan, Gunsu Kimyon Comert, Osman Turkmen, Isin Ureyen, Erdem Fadiloglu, Alper Karalok, Tolga Tasci, Gokhan Tulunay, Derman BasaranAbstractBackgroundTo determine the efficacy of lymphadenectomy and adjuvant radiotherapy in patients with endometrioid-type cancer confined to the uterine corpus.MethodsA total of 323 patients were evaluated. Patients were stratified according to depth of myometrial invasion (DMI) and tumor grade.ResultsLymphadenectomy was performed in 83% of the entire cohort. Age (
To evaluate the relative delivery costs, using time-driven activity-based costing (TDABC), for adjuvant radiation therapy (RT) for high-intermediate risk endometrial cancer.
Adjuvant therapy for stage II endometrial cancer typically includes pelvic external beam radiation. The purpose of this study was to review the outcomes of patients treated with adjuvant vaginal brachytherapy (VB) alone for stage II endometrial carcinoma with inner half cervical stromal invasion. Secondary objective was to identify prognostic factors for recurrence.