Natural age-related slow-wave sleep alterations onset prematurely in the Tg2576 mouse model of Alzheimer ’s disease

Conclusion: Therefore, our results indicate that at plaque-free disease stage, diminished sleep quality is present in Tg2576 mice which resembles aged healthy controls, suggesting an early-onset of sleep-wake deterioration in murine AD. Whether such dis turbances in the natural patterns of sleep could in turn worsen disease progression warrants further exploration.
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research