Communiferulins, farnesylated coumarins from the roots of Ferula communis and their anti-neuroinflammatory activity

AbstractThree new farnesylated coumarins, communiferulins A –C (1–3), and a farnesylated chromone, ferchromone (4), were isolated from the roots of an Apiaceous plantFerula communis. Their structures including the relative configurations were elucidated by a combination of spectroscopic analyses and calculations of the NMR data. Communiferulins A –C (1–3) had dihydrofuran rings fused to C-3 and C-4 of their coumarin moieties, while3 possessed one additional furan ring. HPLC analyses using a chiral column showed1–4 to be racemates, and the absolute configurations of (+)-1, ( –)-1, (+)-2,  and (–)-2 were deduced by comparison of their ECD spectra with TDDFT-calculated spectra. Communiferulins A (1) and B (2), and ferchromone (4) showed inhibitory activities on IL-1 β production from LPS-stimulated microglial cells.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research