Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma

ConclusionOur data indicate upregulation of BRMS1 in high grade astrocytomas which correlates positively withmutant P53 and a poor patient survival. Silencing of BRMS1 inmutant P53 GBM cell lines resulted in a reduced cellular growth and migration/invasion by suppressing the EGFR-AKT/NF-kB signaling pathway. BRMS1 may serve as a predictive biomarker and therapeutic target inmutant P53 GBM.

http://link.springer.com/10.1007/s13402-022-00729-x

Source: Cellular Oncology - October 26, 2022 Category: Cancer & Oncology Source Type: research