APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease

ConclusionsOur findings suggest that the presence ofAPOEε4 at the early Aβ-seeding stage in patient iNs is critical for aggravation of sporadic AD pathology. These results provide insights into the importance ofAPOEε4 expression for the progression and pathogenesis of sporadic AD.

http://link.springer.com/10.1186/s40035-022-00319-9

Source: Translational Neurodegeneration - October 25, 2022 Category: Neurology Source Type: research