Intestinal damage and immune response after experimental blunt abdominal trauma

In conclusion, we detected early morphological intestinal damage associated with high, early detectable intestinal fatty acid–binding protein plasma levels, and a considerable time- and dose-dependent impairment of the gut-blood barrier in a newly established mouse model of blunt AT. It appears to be a sufficient model for further studies of the intestinal immunopathophysiological consequences of AT and the evaluation of novel therapeutic approaches.
Source: Shock - Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research