Blocking domain 6 of high molecular weight kininogen to understand intrinsic clotting mechanisms

CONCLUSIONS: This study improves our understanding of HK-mediated coagulation and provides an explanation for the absence of bleeding in HK-deficient individuals. 3E8 specifically prevented HK-mediated FXI activation; therefore, it could be used to prevent contact activation-mediated thrombosis without altering hemostasis.PMID:36254255 | PMC:PMC9561425 | DOI:10.1002/rth2.12815

Source: Thrombosis and Haemostasis - October 18, 2022 Category: Hematology Authors: Pradeep K Singh Zu-Lin Chen Katharina Horn Erin H Norris Source Type: research