Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

ConclusionsThe intestinal expression of α-syn recapitulates many phenotypic and pathologic features of PD, and induces dysbiosis that aggravates the pathology through the DUOX–ROS–JNK pathway inDrosophila. Our findings provide new insights into the role of intestinal α-syn in PD pathophysiology.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research