Effect of Single Housing on Innate Immune Activation in Immunodeficiency Virus–Infected Pigtail Macaques (Macaca nemestrina) as a Model of Psychosocial Stress in Acute HIV Infection

This study assessed the impact of single housing, as a model of psychosocial stress, on innate immune responses of pigtailed macaques (Macaca nemestrina) during acute SIV infection. Methods A retrospective analysis of acute SIV infection of 2- to si6-year-old male pigtailed macaques was performed to compare the innate immune responses of socially (n = 41) and singly (n = 35) housed animals. Measures included absolute monocyte count and subsets, and in a subset (n ≤ 18) platelet counts and activation data. Results SIV infection resulted in the expected innate immune parameter changes with a modulating effect from housing condition. Monocyte number increased after infection for both groups, driven by classical monocytes (CD14+CD16−), with a greater increase in socially housed animals (227%, p
Source: Psychosomatic Medicine - Category: Psychiatry & Psychology Tags: ORIGINAL ARTICLES Source Type: research