Tbl1x: at the crossroads of transcriptional and post-transcriptional regulation

Located on the X chromosome, the TBL1X gene was first identified in 1999 when its deletion was discovered to be associated with an X-linked human hearing defect, ocular albinism with sensorineural deafness (OASD) 1. Additional TBL1 family members have since been identified and include TBL1X-related 1 (TBL1XR1) located on chromosome 3 and TBL1Y, the Y-linked homologue of TBL1X 2. These genes encode for a family of highly evolutionarily conserved proteins sharing high structural and functional similarities from yeast to human.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research